E174 Silver

E174  medicine, silver is incorporated into wound dressings and used as an antibiotic coating in medical devices. Wound dressings containing silver sulfadiazine or silver nanomaterials are used to treat external infections. Silver is also used in some medical applications, such as urinary catheters (where tentative evidence indicates it reduces catheter-related urinary tract infections) and in endotracheal breathing tubes (where evidence suggests it reduces ventilator-associated pneumonia). The silver ion is bioactive and in sufficient concentration readily kills bacteria in vitro. Silver ions interfere with enzymes in the bacteria that transport nutrients, form structures, and synthesise cell walls; these ions also bond with the bacteria's genetic material. Silver and silver nanoparticles are used as an antimicrobial in a variety of industrial, healthcare, and domestic application: for example, infusing clothing with nanosilver particles thus allows them to stay odourless for longer. Bacteria can, however, develop resistance to the antimicrobial action of silver.E174 Silver compounds are taken up by the body like mercury compounds, but lack the toxicity of the latter. Silver and its alloys are used in cranial surgery to replace bone, and silver–tin–mercury amalgams are used in dentistry.E174  Silver diammine fluoride, the fluoride salt of a coordination complex with the formula , is a topical medicament (drug) used to treat and prevent dental caries (cavities) and relieve dentinal hypersensitivity.